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FINDINGS: EFFECTS OF CANNABIS ON LIVER DISORDERS
Research has shown that cannabidiol (CBD), a major cannabinoid found in cannabis that activates the CB2 receptors of the body’s endocannabinoid system, is therapeutically beneficial for treating many liver disorders (Mallat, et al., 2011).
Studies have shown that CBD can help combat cirrhosis by assisting in the death of hepatic stellate cells (HSCs), which are responsible for the accumulation of scarring on the liver. CBD’s activation of the CB2 receptors, however, has been shown to be effective at inducing apoptosis (death) in these activated HSCs (Lim, Devi & Rozenfeld, 2011).
Research also shows it reduces the force of inflammatory pathways and oxidative tissue injury, therefore limiting the damage caused by cirrhosis (Mukhopadhyay, Rajesh & Pacher, 2011).
CBD has also shown to possess liver protective properties and to promote liver health. CBD was shown to prevent oxidative stress and autophagy from alcohol consumption (Yang, et al., 2014).
One study found that cannabinoids inhibited CYP1A enzymatic activity, meaning it reduced the liver’s risk of toxicity and cancer (Ashino, Hakukawa, Itoh & Numazawa, 2014).
An animal study found that CBD was effective at restoring liver function in mice with liver failure (Avraham, et al, 2011).
Research also suggests that cannabis’ anti-inflammatory and protective properties help in the treatment of hepatitis.
One study found that cannabinoids’ anti-inflammatory properties effectively reduced inflammation of a damaged liver and researchers therefore suggested that cannabis could be developed as a potential drug for hepatitis (Lavon, et al., 2003).
Another study found that cannabinoids appeared have immunosuppressive and profibrogenic effects in patients with chronic hepatitis C (Patsenker, et al., 2015).
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